Progastrin, Novel Blood-Based Biomarker for Detection of Neuroendocrine Neoplasms

Clinicians and researchers at the University of Kentucky Division of Medical Oncology, College of Pharmacy, School of Medicine and Department of Surgical Oncology;  ECS Progastrin in Switzerland;  Centre Hospitalier Lyon-Sud in France;  and Biospecimen Procurement and  the Translational Pathology Shared Resource Facility at Markey Cancer Center in Kentucky have been studying a novel blood-based biomarker for the detection of neuroendocrine neoplasms (NENs) — hPG80 (Progastrin) — and a poster based on their research was presented at ASCO GI in San Francisco, California in January 2020. This first-ever study of plasma hPG80, concludes the authors of the poster, “suggests hPG80 may be a diagnostic blood-based biomarker in both low and high-grade NENs [neuroendocrine neoplasms] and further study is warranted. A prospective trial is ongoing in small cell lung cancer to evaluate its role in monitoring of disease (NCT03958045) and further studies in low-grade NETs [neuroendocrine tumors] are underway.” Aman Chauhan, MD of Markey Cancer Center is the Principal Investigator of the clinical trial.

Progastrin Study, Blood-Based Biomarker for Detection of NENs

This research was supported by the NCI Cancer Center Support Grant (P30 CA177558) as well as ECS Progastrin.

Click here to see the poster.


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