Stephen J. Marx, MD (Endocrinologist, Internist, MEN-1 specialist)

MDBMetabolic Diseases Branch NIDDK, National Institute of Health
10 Center Drive Building 10, Room 9C103
Bethesda, MD 20892
Tel: 301-496-5051
Fax: 301-496-0200

Research Statement: The Genetics and Endocrinology Section studies the genetic bases of primary hyperparathyroidism and its relations to other neoplastic disorders. We have cloned the gene for multiple endocrine neoplasia type 1 and found that it is implicated in many non-hereditary tumors. This tumor suppressor gene encodes a novel protein, menin. We are studying the actions of menin protein by yeast two-hybrid, micro-array, knockout, and other approaches. We have identified an important interaction of menin with junD, a nuclear transcription factor.