This section provides links to consensus findings from leading international and national researchers and physicians in the field of carcinoid and neuroendocrine tumors.
Readers will be able to find answers to debated questions for specific tumors, such as the diagnostic procedure for midgut classic carcinoids, follow-up for appendix carcinoids, or the algorithm for liver metastasis treatment of patients with extrahepatic spread from gut neuroendocrine carcinomas.
Recommendations for radioembolization of hepatic malignancies using Yttrium-90 microsphere brachytherapy.
A consensus panel report from the radioembolization brachytherapy oncology consortium
Int. J. Radiation Oncology Biol. Phys., Vol. 68, No. 1, pp. 13–23, 2007 Full Text PURPOSE: To standardize the indications, techniques, multimodality treatment approaches, and dosimetry to be used for yttrium-90 (Y90) microsphere hepatic brachytherapy. METHODS AND MATERIALS: Members of the Radioembolization Brachytherapy Oncology Consortium met as an independent group of experts in interventional radiology, radiation oncology, nuclear medicine, medical oncology, and surgical oncology to identify areas of consensus and controversy and to issue clinical guidelines for Y90 microsphere brachytherapy.therapies. CONCLUSIONS: Yttrium-90 microsphere therapy is a complex procedure that requires multidisciplinary management for safety and success. Practitioners and cooperative groups are encouraged to use these guidelines to formulate their treatment and dose-reporting policies.
Guidelines for the Management of Gastroenteropancreatic Neuroendocrine Tumours (Including Bronchopulmonary and Thymic Neoplasms)
Members of Nordic the NE Tumour Group: Öberg K, Astrup L, Eriksson B, Falkmer UG, Gustafsen J, Haglund C, Knigge U, Vatn M H and Välimäki M.
Acta Oncologica Vol.43, No 7, 2004 Part I-general overview (pp. 617-625)Full Text
The incidence of neuroendocrine tumours of the gastroenteropancreatic system seems to have increased during the past decade. New diagnostic and therapeutic procedures have aroused the interest of physicians, though most see very few cases of such diseases. A group of members of the Nordic Neuroendocrine Tumour Group decided to compile some guidelines to facilitate the diagnosis and treatment of patients with these tumours. Part I of these guidelines discusses the principles of histopathology, biochemical and radiological diagnosis as well as therapeutic options. Part II-specific NE tumour types (pp 626-636)Full Text
Part II of the guidelines contains a description of epidemiology, histopathology, clinical presentation, diagnostic procedure, treatment, and survival for each type of neuroendocrine tumour. We are not only including gastroenteropancreatic tumours but also bronchopulmonary and thymic neuroendocrine tumours. These guidelines essentially cover basic knowledge in the diagnosis and management of the different forms of neuroendocrine tumour. We have, however, tried to give more updated information about the epidemiology and histopathology, which is essential for the clinical management of these tumours.
Contact: Department of Endocrine Oncology, University Hospital, Uppsala, Sweden. kjell.oberg@medsci.uu.se
This consensus report gives a detailed description of the use of somatostatin analogs in the management of neuroendocrine tumors of the gastroenteropancreatic system. As background information we have outlined critical aspects of the pathology, the use of tumor markers, a definition of functional and non-functional digestive neuroendocrine tumors, different imaging modalities, surgical considerations, liver embolization and the use of cytotoxic drugs as well as interferon. Included in the report is an overview of somatostatin, somatostatin analogs and its receptor expression in different neuroendocrine tumors. It will also define the binding affinities
of different somatostatin analogs to the five different subtypes of somatostatin receptor. We compare the efficacy of octreotide and lanreotide in reducing diarrhea and flushing. Side-effects are described and we provide practical information on somatostatin analog treatment.
Standardisation of Imaging in Neuroendocrine Tumours: Results of a European Delphi Process This link is to the PubMed abstract. From the abstract there are direct lines to the full text article on European Journal of Radiology website (requires subscription payment of membership is a medical society) and the Science Direct website (requires subscription payment.)
By
J. Ricke, K., J. Klose, M. Mignon, K. Öberg, and B. Wiedenmann
European Journal of Radiology, Volume 37, Issue 1, January 2001, Pages 8-17 Diagnostic imaging; Multiple endocrine neoplasia; Neuroendocrine tumours
In 1998 and 1999, a delphi consensus procedure was performed to establish guidelines for standardised diagnostic imaging of neuroendocrine tumours. The procedure included four consecutive workshops of a European group of experts in neuroendocrine tumours as well as feedback given by specialists from the departments of radiology, nuclear medicine, surgery and internal medicine of the according home institutions. Diverging approaches among the centres, which became apparent during the discussion, reflect a lack of controlled studies specifically for rare subgroups of neuroendocrine tumours. This paper summarises the standards for diagnostic imaging as developed during the delphi process. In particular, the diagnostic workflows as well as the technical properties of different imaging modalities are described in detail.
