Shen C, Dasari A, Chu Y, Halperin DM, Zhou S, Xu Y, Shih Y, Yao JC
Ann Oncol. 2017 April 21 [epub ahead of print]
Incidence of locoregional neuroendocrine tumors (NETs) is rising. However, after curative resection, the patterns and risk factors associated with recurrence remain unknown. Consensus guidelines recommend surveillance every 6-12 months for up to 10 years after surgery for resected, well-differentiated NETs irrespective of patient demographics, site, grade or stage of tumor with few exceptions.
Contrary to current guidelines, our study suggests that surveillance recommendations should be tailored according to patient and tumor characteristics. Surveillance past 5 years may be avoided in elderly patients with competing morbidities or low risk of recurrence. Pancreatic, lung, higher grade and regional NETs have a higher risk of recurrence and may be considered for future adjuvant trials.